Conformational B-Cell Epitope Prediction Method Based on Antigen Preprocessing and Mimotopes Analysis
نویسندگان
چکیده
منابع مشابه
Conformational B-Cell Epitope Prediction Method Based on Antigen Preprocessing and Mimotopes Analysis
Identification of epitopes which invokes strong humoral responses is an essential issue in the field of immunology. Various computational methods that have been developed based on the antigen structures and the mimotopes these years narrow the search for experimental validation. These methods can be divided into two categories: antigen structure-based methods and mimotope-based methods. Though ...
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Identification of epitopes which invoke strong humoral responses is an essential issue in the field of immunology. Localizing epitopes by experimental methods is expensive in terms of time, cost, and effort; therefore, computational methods feature for its low cost and high speed was employed to predict B-cell epitopes. In this paper, we review the recent advance of bioinformatics resources and...
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Antibodies have become an indispensable tool for many biotechnological and clinical applications. They bind their molecular target (antigen) by recognizing a portion of its structure (epitope) in a highly specific manner. The ability to predict epitopes from antigen sequences alone is a complex task. Despite substantial effort, limited advancement has been achieved over the last decade in the a...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/257030